Researchers at Imanova publish their own academic research whilst providing a world-class medical imaging service to industry and academia. Read academic publications from Imanova researchers here.

2017

Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson's disease.
Martin-Bastida A, Ward RJ, Newbould R, Piccini P, Sharp D, Kabba C, Patel MC, Spino M, Connelly J, Tricta F, Crichton RR, Dexter DT.
Sci Rep. 2017 May 3;7(1):1398. doi: 10.1038/s41598-017-01402-2.

11 C-DPA-713 has much greater specific binding to translocator protein 18 kDa (TSPO) in human brain than 11 C-( R )-PK11195
Kobayashi M, Jiang T, Telu S, Zoghbi SS, Gunn RN, Rabiner EA, Owen DR, Guo Q, Pike VW, Innis RB, Fujita M.
J Cereb Blood Flow Metab. 2017 Jan 1:271678X17699223. doi: 10.1177/0271678X17699223. [Epub ahead of print]

[11C]PBR28 or [18F]PBR111 detect white matter inflammatory heterogeneity in multiple sclerosis.
Datta G, Colasanti A, Kalk N, Owen DR, Scott G, Rabiner EI, Gunn R, Lingford-Hughes A, Malik O, Ciccarelli O, Nicholas R, Nie L, Battaglini M, De Stefano N, Matthews P.
J Nucl Med. 2017 Mar 16. pii: jnumed.116.187161. doi: 10.2967/jnumed.116.187161. [Epub ahead of print]

Naltrexone ameliorates functional network abnormalities in alcohol-dependent individuals.
Morris LS, Baek K, Tait R, Elliott R, Ersche KD, Flechais R, McGonigle J, Murphy A, Nestor LJ, Orban C, Passetti F, Paterson LM, Rabiner I, Reed L, Smith D, Suckling J, Taylor EM, Bullmore ET, Lingford-Hughes AR, Deakin B, Nutt DJ, Sahakian BJ, Robbins TW, Voon V; ICCAM Consortium.
Addict Biol. 2017 Feb 28. doi: 10.1111/adb.12503. [Epub ahead of print]

Nalmefene Reduces Reward Anticipation in Alcohol Dependence: An Experimental Functional Magnetic Resonance Imaging Study.
Quelch DR, Mick I, McGonigle J, Ramos AC, Flechais RS, Bolstridge M, Rabiner E, Wall MB, Newbould RD, Steiniger-Brach B, van den Berg F, Boyce M, Østergaard Nilausen D, Breuning Sluth L, Meulien D, von der Goltz C, Nutt D, Lingford-Hughes A.
Biol Psychiatry. 2017 Jan 10. pii: S0006-3223(17)30008-2. doi: 10.1016/j.biopsych.2016.12.029. [Epub ahead of print]

Neural substrates of cue reactivity and craving in gambling disorder
E H Limbrick-Oldfield, I Mick, R E Cocks, J McGonigle, S P Sharman, A P Goldstone, P R A Stokes, A Waldman, D Erritzoe, H Bowden-Jones, D Nutt, A Lingford-Hughes and L Clark
Citation: Translational Psychiatry (2017) 7, e992; doi:10.1038/tp.2016.256
Published online 3 January 2017

Decreased hippocampal translocator protein (18 kDa) expression in alcohol dependence: a [11C]PBR28 PET study.
Kalk NJ, Guo Q, Owen D, Cherian R, Erritzoe D, Gilmour A, Ribeiro AS, McGonigle J, Waldman A, Matthews P, Cavanagh J, McInnes I, Dar K, Gunn R, Rabiner EA, Lingford-Hughes AR.
Transl Psychiatry. 2017 Jan 10;7(1):e996. doi: 10.1038/tp.2016.264.

Imaging in Central Nervous System Drug Discovery
Gunn RN, Rabiner EA.
Semin Nucl Med. 2017 Jan;47(1):89-98. doi: 10.1053/j.semnuclmed.2016.09.001. Review.
PMID: 27987561


T2 relaxation mapping MRI of healthy and inflamed gingival tissue
Newbould RD, Bishop CA, Janiczek RL, Parkinson C, Hughes FJ.
Dentomaxillofac Radiol. 2017 Feb;46(2):20160295. doi: 10.1259/dmfr.20160295.
PMID: 27936919

Quantification of Lung PET Images: Challenges and Opportunities
Delphine L Chen, Joseph Cheriyan, Edwin Chilvers, Gourab Choudoury, Christopher Coello, Martin Connell, Marie Fisk, Ashley M Groves, Roger N Gunn, Beverley F Holman, Brian F Hutton, Sarah Lee, William MacNee, Divya Mohan, David Parr, Deepak Subramanian, Ruth Tal-Singer, Kris Thielemans, Edwin JR van Beek, Laurence Vass, Jeremy W Wellen, Ian Wilkinson and Frederick J Wilson
J Nucl Med January 12, 2017 jnumed.116.184796

2016

Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis.
Datta G, Violante IR, Scott G, Zimmerman K, Santos-Ribeiro A, Rabiner EA, Gunn RN, Malik O, Ciccarelli O, Nicholas R, Matthews PM.
Mult Scler. 2016 Nov 30. pii: 1352458516681504. [Epub ahead of print]
PMID: 27903933

Analysis of ageing-associated grey matter volume in patients with multiple sclerosis shows excess atrophy in subcortical regions.
Bishop CA, Newbould RD, Lee JS, Honeyfield L, Quest R, Colasanti A, Ali R, Mattoscio M, Cortese A, Nicholas R, Matthews PM, Muraro PA, Waldman AD.
Neuroimage Clin. 2016 Nov 9;13:9-15.

Role of 18F-fluorodeoxyglucose Positron Emission Tomography in the Monitoring of Inflammatory Activity in Crohn's Disease.
Russo EA, Khan S, Janisch R, Gunn RN, Rabiner EA, Taylor SA, Matthews PM, Orchard TR.
Inflamm Bowel Dis. 2016 Nov;22(11):2619-2629.

Sleep problems and hypothalamic dopamine D3 receptor availability in Parkinson disease.
Pagano G, Molloy S, Bain PG, Rabiner EA, Chaudhuri KR, Brooks DJ, Pavese N.
Neurology. 2016 Nov 2. pii: 10.1212/WNL.0000000000003396. [Epub ahead of print]

Altered PDE10A expression detectable early before symptomatic onset in Huntington's disease.
Niccolini F, Haider S, Reis Marques T, Muhlert N, Tziortzi AC, Searle GE, Natesan S, Piccini P, Kapur S, Rabiner EA, Gunn RN, Tabrizi SJ, Politis M.
Brain. 2015 Oct;138(Pt 10):3016-29. doi: 10.1093/brain/awv214. Epub 2015 Jul 21.

Evidence for GABA-A receptor dysregulation in gambling disorder: correlation with impulsivity.
Mick I, Ramos AC, Myers J, Stokes PR, Chandrasekera S, Erritzoe D, Mendez MA, Gunn RN, Rabiner EA, Searle GE, Galduróz JC, Waldman AD, Bowden-Jones H, Clark L, Nutt DJ, Lingford-Hughes AR.
Addict Biol. 2016 Oct 13. doi: 10.1111/adb.12457. [Epub ahead of print]

Opportunities and considerations for visualising neuroimaging data on very large displays.
Wall MB, Birch D, Yong MY.
F1000Res. 2016 Sep 2;5:2157. eCollection 2016.

The ICCAM platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part B: fMRI description.
McGonigle J, Murphy A, Paterson LM, Reed LJ, Nestor L, Nash J, Elliott R, Ersche KD, Flechais RS, Newbould R, Orban C, Smith DG, Taylor EM, Waldman AD, Robbins TW, Deakin JW, Nutt DJ, Lingford-Hughes AR, Suckling J; ICCAM Platform.
J Psychopharmacol. 2016 Oct 4. pii: 0269881116668592. [Epub ahead of print]

Acute naltrexone does not remediate fronto-striatal disturbances in alcoholic and alcoholic polysubstance-dependent populations during a monetary incentive delay task.
Nestor LJ, Murphy A, McGonigle J, Orban C, Reed L, Taylor E, Flechais R, Paterson LM, Smith D, Bullmore ET, Ersche KD, Suckling J, Tait R, Elliott R, Deakin B, Rabiner I, Lingford-Hughes A, Nutt DJ, Sahakian B, Robbins TW; ICCAM Consortium.
Addict Biol. 2016 Sep 6. doi: 10.1111/adb.12444. [Epub ahead of print]

Quantifying disease activity in fatty-infiltrated skeletal muscle by IDEAL-CPMG in Duchenne muscular dystrophy.
Mankodi A, Bishop CA, Auh S, Newbould RD, Fischbeck KH, Janiczek RL.
Neuromuscul Disord. 2016 Oct;26(10):650-658. doi: 10.1016/j.nmd.2016.07.013. Epub 2016 Jul 28.

Acute and chronic effects of cannabinoids on effort-related decision-making and reward learning: an evaluation of the cannabis 'amotivational' hypotheses.
Lawn W, Freeman TP, Pope RA, Joye A, Harvey L, Hindocha C, Mokrysz C, Moss A, Wall MB, Bloomfield MA, Das RK, Morgan CJ, Nutt DJ, Curran HV.
Psychopharmacology (Berl). 2016 Oct;233(19-20):3537-52. doi: 10.1007/s00213-016-4383-x. Epub 2016 Sep 2.

Evidence of brain inflammation in patients with Human T Lymphotropic Virus type 1 associated myelopathy (HAM): A pilot multi modal imaging study using [11C] PBR28 PET, MR T1w and DWI.
Dimber R, Guo Q, Bishop C, Adonis A, Buckley A, Kocsis A, Owen D, Kalk N, Newbould R, Gunn R, Rabiner E, Taylor GP.
J Nucl Med. 2016 Aug 25. pii: jnumed.116.175083. [Epub ahead of print]

Loss of extra-striatal phosphodiesterase 10A expression in early premanifest Huntington's disease gene carriers.
Wilson H, Niccolini F, Haider S, Marques TR, Pagano G, Coello C, Natesan S, Kapur S, Rabiner EA, Gunn RN, Tabrizi SJ, Politis M.
J Neurol Sci. 2016 Sep 15;368:243-8. doi: 10.1016/j.jns.2016.07.033. Epub 2016 Jul 15.

A Comparison of Magnetization Transfer Methods to Assess Brain and Cervical Cord Microstructure in Multiple Sclerosis.
Lema A, Bishop C, Malik O, Mattoscio M, Ali R, Nicholas R, Muraro PA, Matthews PM, Waldman AD, Newbould RD.
J Neuroimaging. 2016 Aug 5. doi: 10.1111/jon.12377. [Epub ahead of print]

Quantifying disease activity in fatty-infiltrated skeletal muscle by IDEAL-CPMG in duchenne muscular dystrophy
Ami Mankodi, Courtney A. Bishop, Sungyoung Auh, Rexford D. Newbould, Kenneth H. Fischbeck, Robert Janiczek
Neuromuscular Disorders, Published Online:July 29, 2016 DOI: http://dx.doi.org/10.1016/j.nmd.2016.07.013 

Quantification of [11C]Ro15-4513 GABAAα5 specific binding and regional selectivity in humans
Jim FM Myers, Robert A Comley, and Roger N Gunn
J Cereb Blood Flow Metab 0271678X16661339, first published on July 27, 2016 as doi:10.1177/0271678X16661339

Investigation of the Brain Biodistribution of the Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitor [18F]GSK2647544 in Healthy Male Subjects.
Huiban M, Coello C, Wu K, Xu Y, Lewis Y, Brown AP, Buraglio M, Guan C, Shabbir S, Fong R, Passchier J, Rabiner EA, Lockhart A.
Mol Imaging Biol. 2016 Jul 11. [Epub ahead of print]
PMID: 27402093 [PubMed - as supplied by publisher]

Clinical Translation of a 'Click' Labeled 18F-Octreotate Radioligand for Imaging Neuroendocrine Tumors.
Dubash SR, Keat N, Mapelli P, Twyman F, Carroll L, Kozlowski K, Al-Nahhas A Professor, Saleem A, Huiban M, Janisch R, Frilling A Professor, Sharma R, Aboagye E.
J Nucl Med. 2016 May 12;. [Epub ahead of print]
PMID: 27173162 [PubMed - as supplied by publisher]

LSD modulates music-induced imagery via changes in parahippocampal connectivity.
Kaelen M, Roseman L, Kahan J, Santos-Ribeiro A, Orban C, Lorenz R, Barrett FS, Bolstridge M, Williams T, Williams L, Wall MB, Feilding A, Muthukumaraswamy S, Nutt DJ, Carhart-Harris R.
Eur Neuropsychopharmacol. 2016 Apr 12;. [Epub ahead of print]
PMID: 27084302 [PubMed - as supplied by publisher]

In vivo imaging of microglial activation by positron emission tomography with [11 C]PBR28 in the 5XFAD model of Alzheimer's disease.
Mirzaei N, Tang SP, Ashworth S, Coello C, Plisson C, Passchier J, Selvaraj V, Tyacke RJ, Nutt DJ, Sastre M.
Glia. 2016 Mar 9;. [Epub ahead of print]
PMID: 26959396 [PubMed - as supplied by publisher]

Neuroinflammation in treated HIV-positive individuals: A TSPO PET study.
Vera JH, Guo Q, Cole JH, Boasso A, Greathead L, Kelleher P, Rabiner EA, Kalk N, Bishop C, Gunn RN, Matthews PM, Winston A.
Neurology. 2016 Feb 24;. [Epub ahead of print]
PMID: 26911637 [PubMed - as supplied by publisher]

Phosphodiesterase 10A in Schizophrenia: A PET Study Using [11C]IMA107.
Marques TR, Natesan S, Niccolini F, Politis M, Gunn RN, Searle GE, Howes O, Rabiner EA, Kapur S.
Am J Psychiatry. 2016 Feb 19:appiajp201515040518. [Epub ahead of print]
PMID: 26892941

Magnetic resonance imaging reveals the complementary effects of decongestant and Breathe Right Nasal Strips on internal nasal anatomy.
Bishop CA, Johnson SM, Wall MB, Janiczek RL, Shanga G, Wise RG, Newbould RD, Murphy PS.
Laryngoscope. 2016 Feb 10. doi: 10.1002/lary.25906. [Epub ahead of print]
PMID: 26865420

Glucagon increases energy expenditure independently of brown adipose tissue activation in humans.
Salem V, Izzi-Engbeaya C, Coello C, Thomas DB, Chambers ES, Comninos AN, Buckley A, Win Z, Al-Nahhas A, Rabiner EA, Gunn RN, Budge H, Symonds ME, Bloom SR, Tan TM, Dhillo WS.
Diabetes Obes Metab. 2016 Jan;18(1):72-81. doi: 10.1111/dom.12585. Epub 2015 Nov 20.
PMID: 26434748

2015

A putative biomarker signature for clinically effective AKT inhibition: correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway. Cheraghchi-Bashi A, Parker CA, Curry E, Salazar JF, Gungor H, Saleem A, Cunnea P, Rama N, Salinas C, Mills GB, Morris SR, Kumar R, Gabra H, Stronach EA.
Oncotarget. 2015 Dec 8;6(39):41736-49. doi: 10.18632/oncotarget.6153.

Hippocampal Neuroinflammation, Functional Connectivity, and Depressive Symptoms in Multiple Sclerosis.
Colasanti A, Guo Q, Giannetti P, Wall MB, Newbould RD, Bishop C, Onega M, Nicholas R, Ciccarelli O, Muraro PA, Malik O, Owen DR, Young AH, Gunn RN, Piccini P, Matthews PM, Rabiner EA
Biol Psychiatry. 2015 Dec 5;. [Epub ahead of print]
PMID: 26809249 [PubMed - as supplied by publisher]

18F-FLT PET imaging of cellular proliferation in pancreatic cancer.
Lamarca A, Asselin MC, Manoharan P, McNamara MG, Trigonis I, Hubner R, Saleem A, Valle JW.
Crit Rev Oncol Hematol. 2015 Dec 29;. [Epub ahead of print]
PMID: 26778585 [PubMed - as supplied by publisher]

Neural Systems Involved When Attending to a Speaker.
Kamourieh S, Braga RM, Leech R, Newbould RD, Malhotra P, Wise RJ.
Cereb Cortex. 2015 Nov;25(11):4284-98. doi: 10.1093/cercor/bhu325. Epub 2015 Jan 16.
PMID: 25596592

Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers.
Mick I, Myers J, Ramos AC, Stokes PR, Erritzoe D, Colasanti A, Gunn RN, Rabiner EA, Searle GE, Waldman AD, Parkin MC, Brailsford AD, Galduróz JC, Bowden-Jones H, Clark L, Nutt DJ, Lingford-Hughes AR.

Neuropsychopharmacology. 2015 Nov 10;. [Epub ahead of print]
PMID: 26552847 [PubMed - as supplied by publisher]

Quantitative imaging of protein targets in the human brain with PET.
Gunn RN, Slifstein M, Searle GE, Price JC.
Phys Med Biol. 2015 Oct 29;60(22):R363-R411. [Epub ahead of print]
PMID: 26513176 [PubMed - as supplied by publisher]

Impact of image-based motion correction on dopamine D3/D2 receptor occupancy-comparison of groupwise and frame-by-frame registration approaches.
Jiao J, Searle GE, Schnabel JA, Gunn RN.
EJNMMI Phys. 2015 Dec;2(1):15.
PMID: 26501816 [PubMed]

Glucagon Increases Energy Expenditure Independently of Brown Adipose Tissue Activation in Humans.
Salem V, Izzi-Engbeaya C, Coello C, Thomas DB, Chambers ES, Comninos A, Buckley A, Win Z, Al-Nahhas A, Rabiner EA, Gunn RN, Bloom SR, Tan TM, Dhillo WS.
Diabetes Obes Metab. 2015 Oct 5;. [Epub ahead of print]
PMID: 26434748 [PubMed - as supplied by publisher]

Loss of phosphodiesterase 10A expression is associated with progression and severity in Parkinson's disease.
Niccolini F, Foltynie T, Reis Marques T, Muhlert N, Tziortzi AC, Searle GE, Natesan S, Kapur S, Rabiner EA, Gunn RN, Piccini P, Politis M.
Brain. 2015 Oct;138(Pt 10):3003-15. doi: 10.1093/brain/awv219. Epub 2015 Jul 25.
PMID: 26210536

Altered PDE10A expression detectable early before symptomatic onset in Huntington's disease.
Niccolini F, Haider S, Reis Marques T, Muhlert N, Tziortzi AC, Searle GE, Natesan S, Piccini P, Kapur S, Rabiner EA, Gunn RN, Tabrizi SJ, Politis M.
Brain. 2015 Oct;138(Pt 10):3016-29. doi: 10.1093/brain/awv214. Epub 2015 Jul 21.
PMID: 26198591

Dose-finding quantitative FDG PET imaging study with the oral pan-AKT inhibitor GSK2141795 in patients with gynecological malignancies.
Gungor H, Saleem A, Babar S, Dina R, El-Bahrawy M, Curry E, Rama N, Chen M, Pickford E, Agarwal R, Blagden S, Carme S, Salinas C, Madison SJ, Krachey EC, Santiago-Walker A, Smith DA, Morris SR, Stronach EA, Gabra H.
J Nucl Med. 2015 Oct 1;. [Epub ahead of print]
PMID: 26429956 [PubMed - as supplied by publisher]

Human kinetic modelling of the 5-HT6 PET radioligand, 11C-GSK215083, and its utility for determining occupancy at both 5HT6 and 5HT2A receptors by SB742457 as a potential therapeutic mechanism of action in Alzheimer's disease.
Parker CA, Rabiner EI, Gunn R, Searle G, Martarello L, Comley R, Davy M, Wilson AA, Houle S, Mizrahi R, Laruelle M, Cunningham VJ.
J Nucl Med. 2015 Sep 17;. [Epub ahead of print]
PMID: 26383152 [PubMed - as supplied by publisher

The Imperial College Cambridge Manchester (ICCAM) platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part A: Study description.
Paterson LM, Flechais RS, Murphy A, Reed LJ, Abbott S, Boyapati V, Elliott R, Erritzoe D, Ersche KD, Faluyi Y, Faravelli L, Fernandez-Egea E, Kalk NJ, Kuchibatla SS, McGonigle J, Metastasio A, Mick I, Nestor L, Orban C, Passetti F, Rabiner EA, Smith DG, Suckling J, Tait R, Taylor EM, Waldman AD, Robbins TW, Deakin JW, Nutt DJ, Lingford-Hughes AR.
J Psychopharmacol. 2015 Aug 5;. [Epub ahead of print]
PMID: 26246443 [PubMed - as supplied by publisher]

Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancer
Saleem, Azeem;  Searle, Graham E.;  Kenny, Laura M.;  Huiban, Mickael;  Kozlowski, Kasia et al. (2015)
EJNMMI Research vol. 5 (1)

Carbon-11 radiolabelling of organosulfur compounds: (11) C synthesis of the progesterone receptor agonist tanaproget.
Haywood T, Kealey S, Sánchez-Cabezas S, Hall JJ, Allott L, Smith G, Plisson C, Miller PW.
Chemistry. 2015 Jun 15;21(25):9034-8. doi: 10.1002/chem.201501089. Epub 2015 May 12.
PMID: 25965348

Further evaluation of [11C]MP-10 as a radiotracer for phosphodiesterase 10A: PET imaging study in rhesus monkeys and brain tissue metabolite analysis
Lin, Shu Fei;  Labaree, David;  Chen, Ming Kai;  Holden, Daniel;  Gallezot, Jean Dominique et al. (2015)
Synapse vol. 69 (2) p. 86-95

phMRI: methodological considerations for mitigating potential confounding factors.
Bourke JH, Wall MB.
Front Neurosci. 2015 May 7;9:167. doi: 10.3389/fnins.2015.00167. eCollection 2015. Review.
PMID: 25999812

The simplified reference tissue model: Model assumption violations and their impact on binding potential
Salinas, Cristian A.;  Searle, Graham E.;  Gunn, Roger N. (2015)
Journal of Cerebral Blood Flow and Metabolism vol. 35 (2) p. 304-311

In vivo occupancy of the 5-HT1A receptor by a novel pan 5-HT1(A/B/D) receptor antagonist, GSK588045, using positron emission tomography
Comley, Robert A.;  Van Der Aart, Jasper;  Gulyás, Balázs;  Garnier, Martine;  Iavarone, Laura et al. (2015)
Neuropharmacology vol. 92 p. 44-48

Does cannabis affect dopaminergic signaling in the human brain? A systematic review of evidence to date.
Sami MB, Rabiner EA, Bhattacharyya S.
Eur Neuropsychopharmacol. 2015 Aug;25(8):1201-24. doi: 10.1016/j.euroneuro.2015.03.011. Epub 2015 Mar 30.
PMID: 26068702

A dual radiolabelling approach for tracking metal complexes: Investigating the speciation of copper bis(thiosemicarbazonates) in vitro and in vivo
Hueting, Rebekka;  Kersemans, Veerle;  Tredwell, Matthew;  Cornelissen, Bart;  Christlieb, Martin et al. (2015)
Metallomics vol. 7 (5) p. 795-804

Neural Systems Involved When Attending to a Speaker.
Cereb Cortex. 2015 Jan 16. pii: bhu325. [Epub ahead of print]

2014

An evaluation of the brain distribution of [ 11 C]GSK1034702, a muscarinic-1 (M 1) positive allosteric modulator in the living human brain using positron emission tomography.
EJNMMI Research 2014, 4:66

In vivo occupancy of the 5-HT1A receptor by a novel pan 5-HT1(A/B/D) receptor antagonist, GSK588045, using positron emission tomography.
Neuropharmacology. 2014 Dec 2. pii: S0028-3908(14)00433-X. doi: 10.1016/j.neuropharm.2014.11.017. [Epub ahead of print]

The simplified reference tissue model: model assumption violations and their impact on binding potential.
J Cereb Blood Flow Metab. 2014 Nov 26. doi: 10.1038/jcbfm.2014.202. [Epub ahead of print]

Why Are We Failing to Implement Imaging Studies with Radiolabelled New Molecular Entities in Early Oncology Drug Development?
The Scientific World Journal Volume 2014 (2014), Article ID 269605

Henry Wagner Best Paper Award - SNMMI, St Louis, USA, June 2014
PET brain imaging reveals first signs of Huntington’s up to 30 years before onset.
BRC-funded study by London researchers and Imanova could lead to new disease progression blocking treatments.
(Brain phosphodiesterase 10A (PDE-10A) density in early premanifest HD gene carriers.
J Nuclear Medicine 55 (Supplement 1):32.)

Effects of ecstasy on cooperative behaviour and perception of trustworthiness: A naturalistic study
J Psychopharmacol. 2014 Aug 13. pii: 0269881114544775.

Dopamine D3 receptor ligands for drug addiction treatment: update on recent findings
Prog Brain Res. 2014;211:255-75. doi: 10.1016/B978-0-444-63425-2.00011-8.

In vivo assessment of brain white matter inflammation in Multiple Sclerosis with 18F-PBR111 PET
J Nucl Med. 2014 Jun 5. pii: jnumed.113.135129.

Amphetamine induced endogenous opioid release in the human brain detected with [11C]carfentanil PET: replication in an independent cohort
Int J Neuropsychopharmacol. 2014 May 7:1-6.

Connectivity-based functional analysis of dopamine release in the striatum using diffusion-weighted MRI and positron emission tomography
Cereb Cortex. 2014 May;24(5):1165-77. doi: 10.1093/cercor/bhs397.

Phosphodiesterase 10A PET radioligand development program: from pig to human
J Nucl Med. 2014 Apr;55(4):595-601. doi: 10.2967/jnumed.113.131409.

Central 5-HT4 receptor binding as biomarker of serotonergic tonus in humans: a [11C]SB207145 PET study
Mol Psychiatry. 2014 Apr;19(4):427-32. doi: 10.1038/mp.2013.147.

The effect of acutely administered MDMA on subjective and BOLD-fMRI responses to favourite and worst autobiographical memories
Int J Neuropsychopharmacol. 2014 Apr;17(4):527-40. doi: 10.1017/S1461145713001405.

Palladium-mediated oxidative carbonylation reactions for the synthesis of (11) C-radiolabelled ureas
J Labelled Comp Radiopharm. 2014 Apr;57(4):202-8. doi: 10.1002/jlcr.3151.

A graphical method to compare the in vivo binding potential of PET radioligands in the absence of a reference region: application to [11C]PBR28 and [18F]PBR111 for TSPO imaging
J Cereb Blood Flow Metab. 2014 Apr 16. doi: 10.1038/jcbfm.2014.65.

Effect of chronic antipsychotic treatment on striatal phosphodiesterase 10A levels: a [(11)C]MP-10 PET rodent imaging study with ex vivo confirmation
Transl Psychiatry. 2014 Apr 1;4:e376. doi: 10.1038/tp.2014.17.

Age independently affects myelin integrity as detected by magnetization transfer magnetic resonance imaging in multiple sclerosis
Neuroimage Clin. 2014 Mar 31;4:641-8. doi: 10.1016/j.nicl.2014.02.004.

Imaging nicotine- and amphetamine-induced dopamine release in rhesus monkeys with [(11)C]PHNO vs [(11)C]raclopride PET
Neuropsychopharmacology. 2014 Mar;39(4):866-74. doi: 10.1038/npp.2013.286.

Unexpectedly high affinity of a novel histamine H(3) receptor antagonist, GSK239512, in vivo in human brain, determined using PET
Br J Pharmacol. 2014 Mar;171(5):1241-9. doi: 10.1111/bph.12505.

Determination of [11C]PBR28 binding potential in vivo: a first human TSPO blocking study
J Cereb Blood Flow Metab. 2014 Mar 19. doi: 10.1038/jcbfm.2014.46.

Characterising the plasma-target occupancy relationship of the neurokinin antagonist GSK1144814 with PET
J Psychopharmacol. 2014 Mar;28(3):244-53. doi: 10.1177/0269881113517953.

Relationship between glycine transporter 1 inhibition as measured with Positron Emission Tomography and changes in cognitive performances in non-human primates
Neuropsychopharmacology. 2014 Feb 3. doi: 10.1038/npp.2014.4.

Phase II trial of Cetuximab and conformal radiotherapy only in locally advanced pancreatic cancer with concurrent tissue sampling feasibility study
Transl Oncol. 2014 Feb 1;7(1):55-64. eCollection 2014.

The effects of acutely administered 3,4-Methylenedioxymethamphetamine on spontaneous brain function in healthy volunteers measured with arterial spin labeling and blood oxygen level-dependent resting state functional connectivity
Biol Psychiatry. 2014 Jan 10. pii: S0006-3223(14)00005-5. doi: 10.1016/j.biopsych.2013.12.015.

A comparison of the behavior of (64)Cu-acetate and (64)Cu-ATSM in vitro and in vivo
J Nucl Med. 2014 Jan;55(1):128-34. doi: 10.2967/jnumed.113.119917.

Spatio-temporal pharmacokinetic model based registration of 4D PET neuroimaging data
Neuroimage. 2014 Jan 1;84:225-35. doi: 10.1016/j.neuroimage.2013.08.031.

Making drug development visible - and viable
Drug Discov Today. 2014 Jan;19(1):1-3. doi: 10.1016/j.drudis.2013.10.007.

In vivo imaging of cerebral dopamine D3 receptors in alcoholism
Neuropsychopharmacology. 2014 Jan 28. doi: 10.1038/npp.2014.18.

Translational PET imaging research
Neurobiol Dis. 2014 Jan;61:32-8. doi: 10.1016/j.nbd.2013.08.017.

2013

Negishi coupling reactions as a valuable tool for [11C]methyl-arene formation; first proof of principle
Chem Commun (Camb). 2013 Dec 14;49(96):11326-8. doi: 10.1039/c3cc47203e.

Are prescribed benzodiazepines likely to affect the availability of the 18 kDa translocator protein (TSPO) in PET studies?
Synapse. 2013 Dec;67(12):909-12. doi: 10.1002/syn.21681.

Unexpected high affinity of a novel H3 receptor antagonist, GSK239512, in vivo in human brain, determined using positron emission tomography (PET)
British Journal of Pharmacology. 2013. doi: 10.1111/bph.12505.

PET neuroimaging: the elephant unpacks his trunk: comment on Cumming: "PET neuroimaging: the white elephant packs his trunk?"
Neuroimage. 2013 Dec 31. doi: 10.1016/j.neuroimage.2013.12.042.

Quantification of the specific translocator protein signal of 18F-PBR111 in healthy humans: a genetic polymorphism effect on in vivo binding
J Nucl Med. 2013 Nov;54(11):1915-23. doi: 10.2967/jnumed.113.121020.

Resting state synchrony in anxiety-related circuits of abstinent alcohol-dependent patients
Am J Drug Alcohol Abuse. 2013 Nov;39(6):433-40. doi: 10.3109/00952990.2013.846348.

Awake non-human primate brain PET imaging with minimal head restraint: evaluation of GABAA-benzodiazepine binding with 11C-flumazenil in awake and anesthetized animals
J Nucl Med. 2013 Nov;54(11):1962-8. doi: 10.2967/jnumed.113.122077.

A broadly applicable [18F]trifluoromethylation of aryl and heteroaryl iodides for PET imaging
Nat Chem. 2013 Nov;5(11):941-4. doi: 10.1038/nchem.1756.

Bipolar disorder is associated with the rs6971 polymorphism in the gene encoding 18 kDa translocator protein (TSPO)
Psychoneuroendocrinology. 2013 Nov;38(11):2826-9. doi: 10.1016/j.psyneuen.2013.07.007.

Technologies: preclinical imaging for drug development
Drug Discov Today Technol. 2013 Sep;10(3):e343-50. doi: 10.1016/j.ddtec.2012.04.004.

A 3 T sodium and proton composite array breast coil
Magn Reson Med. 2013 Sep 16. doi: 10.1002/mrm.24860.

Monoamine transporter occupancy of a novel triple reuptake inhibitor in baboons and humans using positron emission tomography
J Pharmacol Exp Ther. 2013 Aug;346(2):311-7. doi: 10.1124/jpet.112.202895.

T1-weighted sodium MRI of the articulator cartilage in osteoarthritis: a cross sectional and longitudinal study
PLoS One. 2013 Aug 5;8(8):e73067. doi: 10.1371/journal.pone.0073067.

Non linear mixed effects analysis in PET PK-receptor occupancy studies
Neuroimage. 2013 Aug 1;76:155-66. doi: 10.1016/j.neuroimage.2013.03.006.

Catalytic decarboxylative fluorination for the synthesis of tri- and difluoromethyl arenes
Org Lett. 2013 Jun 7;15(11):2648-51. doi: 10.1021/ol4009377.

Kinetic analysis of drug-target interactions with PET for characterization of pharmacological hysteresis
J Cereb Blood Flow Metab. 2013 May;33(5):700-7. doi: 10.1038/jcbfm.2012.208.

Use of LC-MS for the quality control of radiopharmaceuticals: example of [(18)F]ML10
J Labelled Comp Radiopharm. 2013 May 30;56(6):330-3. doi: 10.1002/jlcr.3023.

Full central neurokinin-1 receptor blockade is required for efficacy in depression: evidence from orvepitant clinical studies
J Psychopharmacol. 2013 May;27(5):424-34. doi: 10.1177/0269881113480990.

Mathematical modelling of [¹¹C]-(+)-PHNO human competition studies
Neuroimage. 2013 Mar;68:119-32. doi: 10.1016/j.neuroimage.2012.11.033.

A non-linear mixed effect modelling approach for metabolite correction of the arterial input function in PET studies.
Veronese M, Gunn RN, Zamuner S, Bertoldo A.
Neuroimage. 2013 Feb 1;66:611-22. doi: 10.1016/j.neuroimage.2012.10.048. Epub 2012 Oct 27.
PMID: 23108277

A generalised spatio-temporal registration framework for dynamic PET data: application to neuroreceptor imaging
Med Image Comput Comput Assist Interv. 2013;16(Pt 1):211-8.

Occupancy of brain dopamine D3 receptors and drug craving: a translational approach
Neuropsychopharmacology. 2013 Jan;38(2):302-12. doi: 10.1038/npp.2012.171.

2012

Orbitofrontal connectivity with resting-state networks is associated with midbrain dopamine D3 receptor availability
Cereb Cortex. 2012 Dec;22(12):2784-93. doi: 10.1093/cercor/bhr354.

A non-linear mixed effect modelling approach for metabolite correction of the arterial input function in PET studies
Neuroimage. 2012 Oct 27;66C:611-622. doi: 10.1016/j.neuroimage.2012.10.048.

Endogenous opioid release in the human brain reward system induced by acute amphetamine administration
Biol Psychiatry. 2012 Sep 1;72(5):371-7. doi: 10.1016/j.biopsych.2012.01.027.

Biodistribution and radiation dosimetry of the serotonin 5-HT6 ligand [11C]GSK215083 determined from human whole-body PET
Mol Imaging Biol. 2012 Aug;14(4):517-521. doi: 10.1007/s11307-011-0523-1.

The development, past achievements, and future directions of brain PET
J Cereb Blood Flow Metab. 2012 Jul;32(7):1426-54. doi: 10.1038/jcbfm.2012.20.

Metal-free oxidative fluorination of phenols with [18F]fluoride
Angew Chem Int Ed Engl. 2012 Jul 2;51(27):6733-7. doi: 10.1002/anie.201201502.

Affinity and selectivity of [¹¹C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo
Synapse. 2012 Jun;66(6):489-500. doi: 10.1002/syn.21535.

Combining PET biodistribution and equilibrium dialysis assays to assess the free brain concentration and BBB transport of CNS drugs
J Cereb Blood Flow Metab. 2012 May;32(5):874-83. doi: 10.1038/jcbfm.2012.1.

In vivo dopaminergic and behavioral responses to acute cocaine are altered in adenosine A(2A) receptor knockout mice
Synapse. 2012 May;66(5):383-90. doi: 10.1002/syn.21527.

Identifying improved TSPO PET imaging probes through biomathematics: the impact of multiple TSPO binding sites in vivo
Neuroimage. 2012 Apr 2;60(2):902-10. doi: 10.1016/j.neuroimage.2011.12.078.

Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [11C]-harmine positron emission tomography study
J Cereb Blood Flow Metab. Mar 2012; 32(3): 443–446. doi: 10.1038/jcbfm.2011.184.

Positron emission tomography molecular imaging for drug development
Br J Clin Pharmacol. 2012 Feb;73(2):175-86. doi: 10.1111/j.1365-2125.2011.04085.x.

Automated preparation of the dopamine D2/3 receptor agonist ligand [11C]-(+)-PHNO for human PET imaging studies
Appl Radiat Isot. 2012 Feb;70(2):380-7. doi: 10.1016/j.apradiso.2011.09.018.

Radiosynthesis and characterization of 11C-GSK215083 as a PET radioligand for the 5-HT6 receptor
J Nucl Med. 2012 Feb;53(2):295-303. doi: 10.2967/jnumed.111.093419.

Radiation dose estimates for carbon-11-labelled PET tracers
Nucl Med Biol. 2012 Feb;39(2):305-14. doi: 10.1016/j.nucmedbio.2011.08.005.

A pharmacokinetic PET study of NK₁ receptor occupancy
Eur J Nucl Med Mol Imaging. 2012 Feb;39(2):226-35. doi: 10.1007/s00259-011-1954-2.

Within-subject comparison of [(11)C]-(+)-PHNO and [(11)C]raclopride sensitivity to acute amphetamine challenge in healthy humans
J Cereb Blood Flow Metab. 2012 Jan;32(1):127-36. doi: 10.1038/jcbfm.2011.115.

An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28
J Cereb Blood Flow Metab. 2012 Jan;32(1):1-5. doi: 10.1038/jcbfm.2011.147.

A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers
PLoS One. 2012;7(12):e51395. doi: 10.1371/journal.pone.0051395.

2011

MR-DTI and PET multimodal imaging of dopamine release within subdivisions of basal ganglia
J. Phys.: Conf. Ser. 317 012005 doi:10.1088/1742-6596/317/1/012005

Translational characterization of [11C]GSK931145, a PET ligand for the glycine transporter type 1
Synapse. 2011 Dec;65(12):1319-32. doi: 10.1002/syn.20966.

Characterization of in vivo pharmacological properties and sensitivity to endogenous serotonin of [11C] P943: a positron emission tomography study in papio anubis
Synapse. 2011 Nov;65(11):1119-27. doi: 10.1002/syn.20946.

The gut hormones PYY 3-36 and GLP-1 7-36 amide reduce food intake and modulate brain activity in appetite centers in humans
Cell Metab. 2011 Nov 2;14(5):700-6. doi: 10.1016/j.cmet.2011.09.010.

Advances in biomathematical modeling for PET neuroreceptor imaging.
Gunn RN, Guo Q, Salinas CA, Tziortzi AC, Searle GE.
Drug Discov Today Technol. 2011 Summer;8(2-4):e45-51. doi: 10.1016/j.ddtec.2012.01.001.
PMID: 24990262

Simultaneous T₂ and lipid quantitation using IDEAL-CPMG
Magn Reson Med. 2011 Nov;66(5):1293-302. doi: 10.1002/mrm.22916.

Presynaptic 5-HT1A is related to 5-HTT receptor density in the human brain
Neuropsychopharmacology. 2011 Oct;36(11):2258-65. doi: 10.1038/npp.2011.113.

Fully automated synthesis of the M₁ receptor agonist [¹¹C]GSK1034702 for clinical use on an Eckert & Ziegler Modular Lab system
Appl Radiat Isot. 2011 Oct;69(10):1390-4. doi: 10.1016/j.apradiso.2011.05.007.

Non-invasive imaging in experimental medicine for drug development
Curr Opin Pharmacol. 2011 Oct;11(5):501-7. doi: 10.1016/j.coph.2011.04.009.

Motion-sensitized driven equilibrium for blood-suppressed T2* mapping
J Magn Reson Imaging. 2011 Sep;34(3):702-9. doi: 10.1002/jmri.22664.

Molecular and functional neuroimaging of human opioid receptor pharmacology
Molecular Psychiatry. 2011 Aug;16:785. doi:10.1038/mp.2011.83

Biodistribution and radiation dosimetry of the glycine transporter-1 ligand 11C-GSK931145 determined from primate and human whole-body PET
Mol Imaging Biol. 2011 Aug;13(4):776-84. doi: 10.1007/s11307-010-0398-6.

Radiosynthesis and in vivo evaluation of [(11)C]MP-10 as a positron emission tomography radioligand for phosphodiesterase 10A
Nucl Med Biol. 2011 Aug;38(6):875-84. doi: 10.1016/j.nucmedbio.2011.02.005.

Pharmacological differentiation of opioid receptor antagonists by molecular and functional imaging of target occupancy and food reward-related brain activation in humans
Mol Psychiatry. 2011 Aug;16(8):826-35, 785. doi: 10.1038/mp.2011.29.

Rapid carbonylative coupling reactions using palladium(I) dimers: applications to 11CO-radiolabelling for the synthesis of PET tracers
Org Biomol Chem. 2011 May;9(9):3499-503. doi: 10.1039/c1ob05268c.

Evaluation of dopamine D2/3 specific binding in the cerebellum for the PET radiotracer [11C]FLB 457: implications for measuring cortical dopamine release
Synapse. 2011 Oct;65(10):991–997. doi: 10.1002/syn.20926

Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy
J Cereb Blood Flow Metab. 2011 Mar;31(3):944-52. doi: 10.1038/jcbfm.2010.175.

Variation in binding affinity of the novel anxiolytic XBD173 for the 18 kDa translocator protein in human brain
Synapse. 2011 Mar;65(3):257-9. doi: 10.1002/syn.20884.

Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligands
J Med Chem. 2011 Jan 13;54(1):366-73. doi: 10.1021/jm101230g.

Imaging dopamine receptors in humans with [11C]-(+)-PHNO: dissection of D3 signal and anatomy
Neuroimage. 2011 Jan 1;54(1):264-77. doi: 10.1016/j.neuroimage.2010.06.044.

Mixed-affinity binding in humans with 18-kDa translocator protein ligands
J Nucl Med. 2011 Jan;52(1):24-32. doi: 10.2967/jnumed.110.079459.

2010

Three-dimensional T(1), T(2) and proton density mapping with inversion recovery balanced SSFP
Magn Reson Imaging. 2010 Nov;28(9):1374-82. doi: 10.1016/j.mri.2010.06.004.

Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation
J Cereb Blood Flow Metab. 2010 Sep;30(9):1608-18. doi: 10.1038/jcbfm.2010.63.

Evaluation of 11C-GSK189254 as a novel radioligand for the H3 receptor in humans using PET
J Nucl Med. 2010 Jul;51(7):1021-9. doi: 10.2967/jnumed.109.071753.

Imaging cortical dopamine D1 receptors using [11C]NNC112 and ketanserin blockade of the 5-HT 2A receptors
J Cereb Blood Flow Metab. 2010 May;30(5):985-93. doi: 10.1038/jcbfm.2009.269.

Improvements in parallel imaging accelerated functional MRI using multiecho echo-planar imaging
Magn Reson Med. 2010 Apr;63(4):959-69. doi: 10.1002/mrm.22222.