Hippocampal Neuroinflammation, Functional Connectivity, and Depressive Symptoms in Multiple Sclerosis - A PET/MRI Study

A study, carried out at Imperial College and Imanova, was performed to characterize the relationship between depressive symptoms and hippocampal microglial activation in patients with Multiple Sclerosis

This study combined PET and MRI measures in looking at the causes of symptoms of depression in MS. PET measures of neuroinflammation in the hippocampus were related to clinical measures of depression and fMRI data on hippocampal functional connectivity.

Results suggest that inflammation in the hippocampus affects its communication with the rest of the brain and this may contribute to the development of depression in MS patients.

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